Suramin, a polysulphonated naphthylurea proven to be an effective anticancer agent against selected tumours, and alpha 2A-interferon (alpha 2A-IFN) were investigated for their combined effects on HCT-8, HCT-15, CL-D, SW-480 and SW-620 human colorectal adenocarcinoma cell lines. All lines were sensitive to clinically achievable concentrations of suramin in a dose-dependent manner, while alpha 2A-IFN alone induced only a modest reduction of cell growth. Concomitant treatment with suramin and alpha 2A-IFN resulted in a synergistic inhibition of cell viability in each cell line at all doses tested. However, when suramin and alpha 2A-IFN were administered sequentially, inhibition of cell viability was clearly dependent on the timing of treatment...
Previous studies have shown that suramin is capable ofdisrupt-ing autocrine growth involving coexpre...
The biological activity of 5'-deoxy-5-fluorouridine (5'-dFUrd) depends upon intracellular enzymatic ...
Gamma-Interferon (IFN-gamma) and the antimetabolites 5-fluorouracil (5-FU) and S-fluoro-2'-deoxyurid...
Suramin, a polysulphonated naphthylurea proven to be an effective anticancer agent against selected ...
The present experiment was undertaken to study what types of human cancers are responsive to the ant...
Suramin has been shown to be of interest as a potential new anticancer agent because of its capacity...
Suramin, a polyanionic compound originally synthesized for use as an antiparasitic agent, has recent...
BACKGROUND: The results of conventional chemotherapy in metastatic colorectal cancer are discouragin...
AIMS AND BACKGROUND: Suramin has been shown to be of interest as a potential new anticancer agent be...
Suramin, a polyanionic compound with known antiparasitic activity, has been shown to be adrenocortic...
textabstractSuramin, a non‐specific growth factor antagonist, is currently under investigation for t...
International audienceSuramin, a drug currently used for advanced malignancy, induces the differenti...
We investigated the effect of toremifene, interferon-alpha2a, interferon-alpha2b and interferon-alph...
: Suramin inhibits the biological activity of human tumor necrosis factor alpha (TNF) through a dire...
The combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN-alpha) has reported activity in t...
Previous studies have shown that suramin is capable ofdisrupt-ing autocrine growth involving coexpre...
The biological activity of 5'-deoxy-5-fluorouridine (5'-dFUrd) depends upon intracellular enzymatic ...
Gamma-Interferon (IFN-gamma) and the antimetabolites 5-fluorouracil (5-FU) and S-fluoro-2'-deoxyurid...
Suramin, a polysulphonated naphthylurea proven to be an effective anticancer agent against selected ...
The present experiment was undertaken to study what types of human cancers are responsive to the ant...
Suramin has been shown to be of interest as a potential new anticancer agent because of its capacity...
Suramin, a polyanionic compound originally synthesized for use as an antiparasitic agent, has recent...
BACKGROUND: The results of conventional chemotherapy in metastatic colorectal cancer are discouragin...
AIMS AND BACKGROUND: Suramin has been shown to be of interest as a potential new anticancer agent be...
Suramin, a polyanionic compound with known antiparasitic activity, has been shown to be adrenocortic...
textabstractSuramin, a non‐specific growth factor antagonist, is currently under investigation for t...
International audienceSuramin, a drug currently used for advanced malignancy, induces the differenti...
We investigated the effect of toremifene, interferon-alpha2a, interferon-alpha2b and interferon-alph...
: Suramin inhibits the biological activity of human tumor necrosis factor alpha (TNF) through a dire...
The combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN-alpha) has reported activity in t...
Previous studies have shown that suramin is capable ofdisrupt-ing autocrine growth involving coexpre...
The biological activity of 5'-deoxy-5-fluorouridine (5'-dFUrd) depends upon intracellular enzymatic ...
Gamma-Interferon (IFN-gamma) and the antimetabolites 5-fluorouracil (5-FU) and S-fluoro-2'-deoxyurid...