A prospective clinical study of management of pregnancy complicated with intauterine fetal death by low dose prostaglandins

Background: This study was conducted to evaluate the effectiveness and side effects of Prostaglandins (vaginal misoprostol) in the termination of second and third trimester pregnancies complicated with intrauterine fetal death.Methods: This study was carried out on 100 women with intrauterine fetal demise in second and third trimester pregnancies collected from Government Medical college and Hospital during the period October 2014 to October 2016.Results: By the application of 25µg of misoprostol in the posterior fornix of vagina every 4 hourly over 24 hours. The progress, adverse effects and outcomes were assesed. The success rate was 92.76% and 64.52% in women with third and second trimesters respectively. The mean induction delivery interval was 15.67±9.64 and 24.94±8.23 for women with third and second trimesters respectively. The induction delivery interval correlated negatively with the duration of gestation. The mean value of total required dose was 192.42±128.99 and 361.29±139.92 for women with third and second trimesters respectively.Conclusions: Low dose misoprostol appears to be safe, effective, practical and inexpensive method for termination of third trimester pregnancies compared to second trimester complicated with intauterine fetal death and its effects increases with duration of gestation