Gene expression data analysis with DNA microarray technology has become a fundamental tool in genomic research. DNA Microarray technology monitors the gene expression levels of thousands of genes at a time under a certain condition makes them suit-able for a quite lot of biological applications. As the Association rules are widely using in market-basket analysis, these rules can also be applied in biological problems. Association rules play an important role in the computational biology. In this paper, how the Association rule mining is important for micro array gene association analysis have been discussed. Though the clustering offers a natural solution to these bio-logical problems by discovering frequent item sets on microarray data and...