Synthesis and A Suggestion Mechanism on Biological Evaluation of Amino Acid-Schiff Base Ligands and Co(II), Cu(II) and Ni(II) Complexes

This study aimed to investigate of the antimicrobial activities of some amino acid-Schiff bases complexes as theoretical aspects. Co(II), Cu(II) and Ni(II) complexes of N, N'-(1,4-phenylenedimetiliden) bis DL-Alanine and N, N'-(1,4-phenylendimetiliden) bis DL-Glisine were been prepared and characterized. The antibacterial and antifungal activities were measured by Disc diffusion and MIC method against gram-positive bacteria i. e. Psydomamonas aeruginosa ATCC 29212, Bacillus subtilis RSKK 244, Bacillus megaterium(clinical isolate), gram-negative bacteria Micrococcus Luteus NRRLB and as fungus Candida albicans. The antibiogram tests of amino acid-Schiff bases complexes showed better results than some known antibiotics. Especially Cu(II) complexes were more potent bacteridal than all of the substances synthesized. Furthermore a mechanism of reaction was offered in the explanation of these observation. Some of the compounds exhibited activity comparable to Ketoconazole, Ampicillin, Tetracycline, Penicillin, Gentamisin and Chloroamphenicol.Gazi University Scientific Research FundGazi University [05/2007-02, 05/2010-03]The authors thank to the Gazi University Scientific Research Fund (Project number: 05/2007-02 and 05/2010-03) for the financial support provided for this study and Ozge Cicek, Esra Yildirim, Yasemin Sahin and Refiye Tekiner for carryings out laboratory studies