This study demonstrates an application of multi-loop Model Reference Adaptive Control (MRAC) structure for enhancement of fault tolerance performance of closed-loop PID control systems. The presented multi-loop MRAC-PID control structure can be used to transform a conventional PID control system to an adaptive control system by combining an outer adaptation loop. This study shows that the proposed control structure can improve fault tolerance and fault detection performance of the existing closed-loop PID control systems without modifying any coefficients of PID controllers, and this asset is very useful for increasing robust control performance of the existing industrial control systems. This advantage originates from the reference input s...