Determination of Selected Acidic Pharmaceuticals and Caffeine in Ergene Basin, in Turkey

In this study, surface and wastewater in Corlu, Tekirdag has been monitored for ibuprofen, naproxen and diclofenac as non-steroidal anti-inflammatory drugs (NSAIDs), salicylic acid as an analgesic and caffeine. For this goal, samples were collected from 5 areas during winter and summer times (W1, W2, W3, W4 and W5) working in the field of a wastewater treatment plant site, only Cerkezkoy industrial district W4. Different solid-phase extractions, pH and derivatization conditions were tested with some anti-inflammatory drugs and caffeine of Gas-Chromatography-Mass Spectrometry in environment samples and their identification and quantification at trace levels were made (ng L-1). Diclofenac (LOQ = 4.3 ng L-1) and ibuprofen (LOQ = 134.1 ng L-1) could not be determined. Other concentration levels of arranged drugs range between 2.12 -13.58 ng L-1 naproxen, 15.74-18.74 ng L-1 salicylic acid and 5.8-121.2 ng L-1 caffeine.Trakya University Scientific Research ProjectTrakya University [TUBAP-120]This study was supported by the Trakya University Scientific Research Project TUBAP-120. The authors acknowledge TUBITAK Marmara Research Center for the measurement of physicochemical parameters and also Prof. Dr. Hilmi IBAR for the technical support he provided at his own laboratory. Acknowledgment is also given to Assistant Professor Kenan Sezer and Erasmus student Mujgan Halil for their great efforts during the study