Synthesis of Novel Pyrrolo[3,2-c]carbazole and Dipyrrolo[3,2-c: 2 ',3 '-g]carbazole Derivatives

Pyrrolocarbazole and dipyrrolocarbazoles have been synthesized via the Hemetsberger indole synthesis, starting from 9-ethyl carbazole-3-carbaldehyde and 9-ethylcarbazole-3,6-dicarbaldeyde, respectively. The pyrrolocarbazole structures were confirmed through H-1 NMR, C-13 NMR, IR, mass spectrometry and single crystal X-ray diffraction techniques. The targeted compounds showed potent in vitro cytotoxicity against human colon cancer HT29 cells.TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z159]This work was funded by TUBITAK grant 113Z159 to E.A., I.F.S., and H.K. We thank the NMR facility of Gebze Technical University