Seizure Induced by Extended-Release Bupropion Used for Smoking Cessation at Early Term and Therapeutic Dose

Bupropion inhibits reuptakes of dopamine and noradrenaline. Since it is also a nicotine receptor antagonist, it acts as a drug used for smoking cessation. Bupropion is commonly preferred because of no side effects on weight, sexual function, and the lack of sedative effect. Immediate and sustained-release bupropion forms may trigger seizure activity. In the present article, we report a case of a 30-year-old man presenting with generalized tonic clonic seizures induced by extended-release bupropion. We also emphasized that extended-release bupropion, which is commonly used for smoking cessation therapy, may cause seizure at early term and therapeutic dose