Metabolic aspects of n-3 PUFAs supplementation to rat cardiomyocytes: a HR-MAS NMR and GC/MS study

Cardiovascular diseases (CVD) are responsible for significant morbidity and mortality throughout the world. We present a first investigation using HR-MAS NMR Spectroscopy in combination with GC/MS of neonatal rat cardiomyocytes supplemented with two different PUFAs, EPA and DHA, in order to understand the metabolic change occurring in these cells following the increase of their n-3 PUFA content. EPA and DHA are of special importance for human health, and fish oil feeding has beenassociated to reduced mortality in several studies