A study of the immunological and biochemical changes of COVID-19 patients and the gene expression of their Nrf2 gene in southren Iraq

This study was to determine the effect of the Coronavirus in samples (blood and serum) and its association with biochemical and immunological parameters and some factors including age, gender, clinical symptoms, and chronic diseases. 100 samples of COVID-19 patients (male and female) were collected in southern Iraq for 3 months (March 1 - 1 June). The results of this study showed (84% severe state and 16% critical state). High levels of ferritin in the severe case of COVID-19 patients, while D-dimer high levels in the critical cases of COVID-19 patients. CRP and WBC are at high levels in critical cases for COVID-19 patients. While the platelet levels of COVID-19 patients were low in critical cases.RT-PCR examined NRF2 gene expression to determine gene expression levels 5'- A/GTGACNNNGC, its relationship with COVID-19, and biochemical and immunological parameters. High levels of gene expression in severe cases and we did not find any effect of gender or age on gene expression levels NRF2. Parameter levels were not affected by the gender of the patient when infected with COVID-19. While platelet levels were high in females, due to some physiological factors.&nbsp