Evaluation of osteocalcin and osteopontin among women with osteoporosis in Wasit province, Iraq

Background: Osteoporosis (OP) is one of the most common metabolic diseases, characterized by low bone mass and abnormal bone microarchitecture leading to the development of fractures and subsequent disability. Disruption of bone remodeling by osteoporosis results in an imbalance between bone formation by osteoblasts and resorption by osteoclasts. Aims: This study was aimed to investigate relationship between Osteocalcin and Osteopontin, with estimating their effects on osteoporosis in women and the benefits in diagnosis. Materials and method: In this study, 50women who were referred to DEXA unit in Al-Karama Teaching Hospital to diagnosed with Osteoporosis. They were compared with 40 healthy individuals who did not have any clinical symptoms. Blood samples were used after separating them by a centrifuge for the purpose of examining levels of vital indicators were detected by Enzyme linked immunosorbent assay (ELISA). Results: The results of the current study showed a decrease in the level of Osteocalcin, increasing in the levels of Osteopontin, with significant differences between the study groups at P≤0.0001 compared to the control group. osteoporosi