Formulation and evaluation of nano-particulate topical gel containing Celecoxib

The present research work describes formulation and evaluation of celecoxib containing gel using transdermal delivery. Transdermal potential of nanoparticulate gel was investigated using in-vitro and in-vivo study. In present study procured drug samples were investigated under preformulation studies. For development of nanparticles containing celecoxib, nanoprecipitation method is used. The formulated nanoparticles were evaluated for different parameters such as zeta potential, particle size, % entrapment efficiency, in-vitro drug release, SEM and stability studies. The formulated nanoparticles were formulated as gel using carbopol. Formulated carbopol gels were characterized for appearance, spreadability, pH, viscosity, drug content, consistency index and ex-vivo drug release, in-vitro drug release. Formulated gels were evaluated for in-vitro studies (skin irritation and skin permeation). Further evaluated for stability studies as per ICH guidelines, results of stability studies reveled that both the formulated gels were found to be stable at stuied temperatures