Evaluation of antioxidant and oxidant status, including levels of Malondialdehyde (MDA) and Superoxide Dismutase (SOD), in the Indian population with alopecia areata

Abstract: Hair loss is caused by alopecia areata (AA), which is a non-scarring inflammatory and autoimmune disorder. The aetio pathogenesis of alopecia areata is uncertain, however autoimmune, genetic predisposition, emotional, and environmental stress are all thought to have a role in its development. Antioxidant/oxidant balance disruption is a common sign of autoimmune, psychological, and environmental stress. As a result, our research looks at the effects of oxidative stress in alopecia areata. Materials and Methods: This was observational prospective study, The present study included 150 A.A patients(cases) and 150 controls attended to Department of Dermatology in collaboration with Department of Biochemistry, LN Medical College and Research center & J.K Hospital, Bhopal. The levels of Iron and Ferritin was estimated by colorimetric Method   Results:  A total of 300(150 cases of AA +150 controls were included SOD & MDA with mean+ SD are given in the Table no.1. The two groups were comparable (P<0.0001), (P<0.0001).  The difference in the values SOD and MDA parameters in respect of these groups was highly statistically significant (P<0.0001*)