Comparison of HER-2/neu with histological grade and hormone (ER, PR) status in carcinoma breast

Objectives :- The study was performed with the aim to compare HER-2/neu over expression with age, size of tumor, histopathological type, grade of tumor, lymph node positivity, NPI, and hormone receptors ER and PR. Methods :- The study was conducted on 66 cases of breast carcinoma. All the cases underwent immunohistochemistry for ER, PR and HER-2/neu over expression. HER-2/neu over expression was compared with prognostic factors. Results :- The age range of these patients was from 30-70 years with mean age of 49.92 years. HER-2/neu was strongly positive (score 3) in 12/66 ( 18.18%), moderate or equivocal ( score 2) in 7 /66 (10.60 %) and mild ( score 1) in 16/66 (24.24%) and it was negative ( score 0) in 31/66 (46.97 %). Estrogen Receptor ( ER) was positive in 38/66 (57.57%) cases, progesterone receptors (PR) was positive in 30/66 (45.45%) cases. Triple negative cases were 16/66 (24.24%) and triple receptor positive cases were 04/66 (6.06%).&nbsp