Evaluation of reference models for [11C]ABP688 targeting the metabotropic glutamate receptor 5 in rats\u2014application to an epilepsy model

The cerebellum is a suitable referenceregion for the quantification of mGluR5 availabilitywith [11C]ABP688. Blood sample based quantificationof BPnd correlates well with reference regionbased analyses. Scan duration of 50 mins is required.The observed increase in receptor density in humans(hippocampal specimens) suffering from temporallobe epilepsy was not observed in the pilocarpinemodel, but the stastical power has to be increased toconfirm these results. The present results in thepilocarpine model contrast with the immunohistochemicalstudies in humans but are in agreementwith receptor binding studies conducted by ourgroup