Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of both upper and lower motor neurons. Astrocytes are key for maintaining central nervous system homeostasis and are important determinants of motor neuron fate in ALS. Accordingly, IPSC-derived astrocytes from ALS patients or astrocytes from diverse ALS mouse models, including mice overexpressing the ALS-linked mutant hSOD1G93A, induce motor neuron death in co-culture. Previously our lab reported that motor neurons isolated from receptor for advanced glycation end products (RAGE) knockout mice are resistant to the ALS-astrocyte derived neurotoxicity. Therefore, our working hypothesis states that inhibition of RAGE signaling can suppress astrocyte-mediated ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease due to motor neuron (MN) lo...
Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing neurodege...
Amyotrophic lateral sclerosis (ALS) is a devastating late-onset neurodegenerative disease that mainl...
Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron degenerative dis...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a progress...
The etiology of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disorder characterized by ...
Neuroinflammation is one of the major players in amyotrophic lateral sclerosis (ALS) pathogenesis, a...
Abstract Background Burgeoning evidence highlights seminal roles for microglia in the pathogenesis o...
Neuroinflammation is one of the major players in amyotrophic lateral sclerosis (ALS) pathogenesis, a...
Astrocytes emerge as key players in motor neuron degeneration in Amyotrophic Lateral Sclerosis (ALS)...
Motor neuron death in amyotrophic lateral sclerosis (ALS) is considered a "non-cell autonomous" proc...
Amyotrophic lateral sclerosis (ALS) is a late-onset devastating degenerative disease mainly affectin...
Amyotrophic Lateral Sclerosis (ALS) is a fatal motor neuron (MN) disease with astrocytes implicated ...
Amyotrophic Lateral Sclerosis is a progressively lethal motor neuron disease with no known cure. Gen...
Several causes have been suggested to contribute to amyotrophic lateral sclerosis (ALS) aetiology an...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease due to motor neuron (MN) lo...
Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing neurodege...
Amyotrophic lateral sclerosis (ALS) is a devastating late-onset neurodegenerative disease that mainl...
Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron degenerative dis...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a progress...
The etiology of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disorder characterized by ...
Neuroinflammation is one of the major players in amyotrophic lateral sclerosis (ALS) pathogenesis, a...
Abstract Background Burgeoning evidence highlights seminal roles for microglia in the pathogenesis o...
Neuroinflammation is one of the major players in amyotrophic lateral sclerosis (ALS) pathogenesis, a...
Astrocytes emerge as key players in motor neuron degeneration in Amyotrophic Lateral Sclerosis (ALS)...
Motor neuron death in amyotrophic lateral sclerosis (ALS) is considered a "non-cell autonomous" proc...
Amyotrophic lateral sclerosis (ALS) is a late-onset devastating degenerative disease mainly affectin...
Amyotrophic Lateral Sclerosis (ALS) is a fatal motor neuron (MN) disease with astrocytes implicated ...
Amyotrophic Lateral Sclerosis is a progressively lethal motor neuron disease with no known cure. Gen...
Several causes have been suggested to contribute to amyotrophic lateral sclerosis (ALS) aetiology an...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease due to motor neuron (MN) lo...
Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing neurodege...
Amyotrophic lateral sclerosis (ALS) is a devastating late-onset neurodegenerative disease that mainl...