Use of lanthanide-grafted inorganic nanoparticles as effective contrast agents for cellular uptake imaging

The improvement of commonly used Gd3+-based MRI agents requires the design of new systems with optimized in ViVo efficacy, pharmacokinetic properties, and specificity. To design these contrast agents, two parameters are usually considered: increasing the number of coordinated water molecules or increasing the rotational correlation time by increasing molecular weight and size..