Haemodiafiltration does not lower protein-bound uraemic toxin levels compared with haemodialysis in a paediatric population
- Saoussen, Krid
- Litwin, Mieczyslaw
- Obrycki, Lukasz
- Paglialonga, Fabio
- Ranchin, Bruno
- Samaille, Charlotte
- Schaefer, Franz
- Schmitt, Claus Peter
- Spasojevic, Brankica
- Stefanidis, Constantinos J.
- Shroff, Rukshana
- Eloot, Sunny
- Snauwaert, Evelien
- Van Biesen, Wim
- Raes, Ann
- Glorieux, Griet
- Vande Walle, Johan
- Roels, Sanne
- Vanholder, Raymond
- Askiti, Varvara
- Azukaitis, Karolis
- KARABAY BAYAZIT, AYSUN
- CANPOLAT, Nur
- Fischbach, Michel
Publication date
January 2020
DOI Publisher
Oxford University Press (OUP) Journal
Nephrology Dialysis TransplantationAbstract
Background. Haemodiafiltration (HDF) is accepted to effectively lower plasma levels of middle molecules in the long term, while data are conflicting with respect to the additive effect of convection on lowering protein-bound uraemic toxins (PBUTs). Here we compared pre-dialysis beta 2-microglobulin (beta 2M) and PBUT levels and the percentage of protein binding (%PB) in children on post-dilution HDF versus conventional high- (hf) or low-flux (lf) haemodialysis (HD) over 12 months of treatment
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