Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial
- De Baerdemaeker, L.
- Gregoretti, C.
- Hedenstierna, G.
- Hemmes, S. N.
- Hiesmayr, M.
- Hollmann, M. W.
- Teichmann, R.
- Kiss, T.
- Bobek, I.
- Canet, J.
- Cinnella, G.
- Jaber, S.
- Laffey, J. G.
- Licker, M. J.
- Markstaller, K.
- Matot, I.
- Mueller, G.
- Mills, G. H.
- Mulier, J. P.
- Putensen, C.
- Rossaint, R.
- Schmitt, J.
- Serpa Neto, A.
- Severgnini, P.
- Sprung, J.
- Melo, M. F. Vidal
- Wrigge, H.
- Schultz, M. J.
- Pelosi, P.
- de Abreu, M. Gama
- Senturk, M.
- Bluth, T.
Publication date
March 2021
DOI Publisher
Springer Science and Business Media LLC Journal
TrialsAbstract
Background: Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on PPCs are uncertain. We hypothesized that intraoperative mechanical ventilation using high PEEP with periodic recruitment maneuvers, as compared with low PEEP without recruitment maneuvers, prevents PPCs in obese patients
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