Introduction: The biological significance of sequence variants in form of SNPs needs to be carefully evaluated, as conflicting associations with cancer predisposition have been reported. Haplotypes, the combination of closely linked alleles on a chromosome, play key roles in the study of the genetic basis of disease. There is strong evidence that different polymorphisms within a single gene in cis position can interact to create a large effect on the observed phenotype. Several polymorphisms have been reported in the p53 gene. Some of these are within the coding region and may affect the function of the p53 protein, others are within introns or non-coding regions, and their significance is unclear. In this study, we investigated the associa...
Breast cancer is the most common female cancer, but it has relatively low rates of p53 mutations, su...
Background: TP53 is one of major tumour suppressor genes being essential in preservation of genome i...
The TP53 Arg72Pro polymorphism encodes two p53 variants with different biochemical properties. Here ...
Background: P53 is a tumor suppressor gene and plays important role in the etiology of breast cancer...
Variations in the TP53 gene have been suggested to play a role in many cancers, including breast. We...
<div><p>Variations in the <i>TP53</i> gene have been suggested to play a role in many cancers, inclu...
Increased and deregulated proliferative activity due to abnormalities in the cell cycle modulators a...
<p><strong>Background:</strong> The TP53 gene is the most important tumor suppressor gene in humans....
BACKGROUND AND OBJECTIVE: Breast cancer is most common cancer among women in the world and one third...
Background: Breast cancer is one of the most common cancers in Iranian women. The p53 gene plays a p...
Background: Breast cancer is one of the most common cancers in Iranian women. The p53 gene plays a p...
Background: TP53 is one of major tumour suppressor genes being essential in preservation of genome i...
Background:Many case-control investigations have showed the correlation of TP53 gene polymorphisms w...
There is evidence that carcinoma develops through an accumulation of mutations in the cellular DNA. ...
The TP53 Arg72Pro polymorphism encodes two p53 variants with different biochemical properties. Here ...
Breast cancer is the most common female cancer, but it has relatively low rates of p53 mutations, su...
Background: TP53 is one of major tumour suppressor genes being essential in preservation of genome i...
The TP53 Arg72Pro polymorphism encodes two p53 variants with different biochemical properties. Here ...
Background: P53 is a tumor suppressor gene and plays important role in the etiology of breast cancer...
Variations in the TP53 gene have been suggested to play a role in many cancers, including breast. We...
<div><p>Variations in the <i>TP53</i> gene have been suggested to play a role in many cancers, inclu...
Increased and deregulated proliferative activity due to abnormalities in the cell cycle modulators a...
<p><strong>Background:</strong> The TP53 gene is the most important tumor suppressor gene in humans....
BACKGROUND AND OBJECTIVE: Breast cancer is most common cancer among women in the world and one third...
Background: Breast cancer is one of the most common cancers in Iranian women. The p53 gene plays a p...
Background: Breast cancer is one of the most common cancers in Iranian women. The p53 gene plays a p...
Background: TP53 is one of major tumour suppressor genes being essential in preservation of genome i...
Background:Many case-control investigations have showed the correlation of TP53 gene polymorphisms w...
There is evidence that carcinoma develops through an accumulation of mutations in the cellular DNA. ...
The TP53 Arg72Pro polymorphism encodes two p53 variants with different biochemical properties. Here ...
Breast cancer is the most common female cancer, but it has relatively low rates of p53 mutations, su...
Background: TP53 is one of major tumour suppressor genes being essential in preservation of genome i...
The TP53 Arg72Pro polymorphism encodes two p53 variants with different biochemical properties. Here ...