The intrinsic signal(s) responsible for the onset of human keratinocyte terminal differentiation is not yet fully understood. Evidence has been recently accumulated linking the phospholipase-mediated activation of protein kinase C to the coordinate changes in gene expression occurring during keratinocyte terminal differentiation. Here we report the purification of a keratinocyte-derived protein enhancing protein kinase C enzymatic activity. The stimulator eluted as a peak with estimated molecular mass of approximately 70 kDa, while analysis by SDS-PAGE showed a 30 kDa protein migrating as a distinct doublet, suggesting the formation of a 30 kDa homodimer. The amino acid sequence analysis allowed the unambigous identification of the protein ...
A diverse array of molecules involved in signal transduction have recently been recognised as contai...
Terminal differentiation of skin keratinocytes is a vertically directed multi-step process that is t...
Background: Keratin 15 (K15) is a type I keratin that is used as a marker of stem cells. Its express...
The intrinsic signal(s) responsible for the onset of human keratinocyte terminal differentiation is ...
The intrinsic signal(s) responsible for the onset of human keratinocyte terminal differentiation is ...
Through the use of a keratinocyte/fibroblast co-culture system, we have recently identified a potent...
Desmosomes are prominent cell-cell adhesive junctions in stratified squamous epithelia and disruptio...
Normal human epidermal keratinocytes (NHEK) grown in serum-free medium on a plastic substrate sponta...
Staurosporine (stsp) induces assembly of cornified envelopes in mouse keratinocyte cultures. To clar...
The 14-3-3 protein family controls diverse biochemical processes through interaction with phosphoryl...
Proper epidermal keratinocyte differentiation, which is necessary for cutaneous barrier function, is...
Previously, we have demonstrated that keratinocyte releasable stratifin, also known as 14-3-3 σ prot...
1To whom correspondence should be addressed Our previous results and data in the literature have sug...
During differentiation, keratinocytes undergo a dramatic shape change from small and round to large ...
The novel protein kinase C (nPKC) isoforms are important regulators of human involucrin (hINV) gene ...
A diverse array of molecules involved in signal transduction have recently been recognised as contai...
Terminal differentiation of skin keratinocytes is a vertically directed multi-step process that is t...
Background: Keratin 15 (K15) is a type I keratin that is used as a marker of stem cells. Its express...
The intrinsic signal(s) responsible for the onset of human keratinocyte terminal differentiation is ...
The intrinsic signal(s) responsible for the onset of human keratinocyte terminal differentiation is ...
Through the use of a keratinocyte/fibroblast co-culture system, we have recently identified a potent...
Desmosomes are prominent cell-cell adhesive junctions in stratified squamous epithelia and disruptio...
Normal human epidermal keratinocytes (NHEK) grown in serum-free medium on a plastic substrate sponta...
Staurosporine (stsp) induces assembly of cornified envelopes in mouse keratinocyte cultures. To clar...
The 14-3-3 protein family controls diverse biochemical processes through interaction with phosphoryl...
Proper epidermal keratinocyte differentiation, which is necessary for cutaneous barrier function, is...
Previously, we have demonstrated that keratinocyte releasable stratifin, also known as 14-3-3 σ prot...
1To whom correspondence should be addressed Our previous results and data in the literature have sug...
During differentiation, keratinocytes undergo a dramatic shape change from small and round to large ...
The novel protein kinase C (nPKC) isoforms are important regulators of human involucrin (hINV) gene ...
A diverse array of molecules involved in signal transduction have recently been recognised as contai...
Terminal differentiation of skin keratinocytes is a vertically directed multi-step process that is t...
Background: Keratin 15 (K15) is a type I keratin that is used as a marker of stem cells. Its express...