The Effect of ZAP-70 Expression on Disease Progression in Early-Stage (Binet A) B-CLL Patients

Objectives: Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with various clinical findings. Prognostic markers predicting the clinical outcome in early-stage CLL would play a major role in disease management. Various studies have shown that zeta-associated protein 70 (ZAP-70) provides significant prognostic information This retrospective, single-centre study evaluates the effect of ZAP-70 on disease progression in early-stage B-CL