A series of new 1,2,4-benzothiadiazine derivatives with an arylpiperazine mojety linked at position 3 of the heterocyclic ring were synthesized and assessed for their pharmacological profiles at alpha(1)-adrenoceptor subtypes (alpha(1A), alpha(1B) and alpha(1D)) by functional experiments and by in vitro binding studies at human cloned 5-HT1A receptor. Compound I was identified as a novel (alpha(1D) antagonist (pK(b)alpha(1D) = 7.59; alpha(1D)/alpha(1A) > 389; alpha(1D)/alpha(1B) = 135) with high selectivity over 5-HT1A receptor (5-HT1A/alpha(1D) < 0.01), while compound 6, a 3,4-dihydro-derivative, was characterized as a novel 5-HT1A receptor ligand, highly selective over alpha(1D)-adrenoceptor subtype (pK(i)5-HT1A = 8.04; 5-HT1A/alpha(1D) =...
Following our research project aimed at obtaining new compounds with high affinity and selectivity t...
We report the design and synthesis of a new class of piperazine-pyridazinone analogs. The arylpiper...
This paper reports the microwave-assisted synthesis and the binding assays on the 5-HT1A, 5-HT2A and...
A series of new 1,2,4-benzothiadiazine derivatives with an arylpiperazine mojety linked at position ...
A series of new 1,2,4-benzothiadiazine derivatives with an arylpiperazine mojety linked at position ...
A series of novel 1,2,3-benzotriazin-4-ones I (R = H, Cl, MeO, F, 3-CF3O; n = 2, 3) were prepd. and ...
The analogues 2-5 of the potent 5-HT1A receptor agonist and α1d-adrenoceptor (α1d-AR) antagonist 1 ...
In the continuing search for selective alpha(1)-adrenoceptor (AR) antagonists, new alkoxyarylpiperaz...
A series of aralkylphenoxyethylamine and aralkylmethoxyphenylpiperazine compounds was synthesized an...
We report the design and synthesis of a new class of piperazine-pyridazinone analogues. The arylpipe...
A number of 1- and 2-(4-arylpiperazinylalkyl)-4-(benzoyl)-1,2,3-triazole derivatives (1–4) were prep...
We report the design and synthesis of a new class of piperazine- pyridazinone analogues. The arylpip...
A still unknown tricyclic heterocyclic system (5) was synthesized from 6-hydroxy-2-methylpyridazin-3...
N'-Cyanoisonicotinamidine derivatives, linked to an arylpiperazine moiety, were prepared to identify...
Following our research project aimed at obtaining new compounds with high affinity and selectivity t...
We report the design and synthesis of a new class of piperazine-pyridazinone analogs. The arylpiper...
This paper reports the microwave-assisted synthesis and the binding assays on the 5-HT1A, 5-HT2A and...
A series of new 1,2,4-benzothiadiazine derivatives with an arylpiperazine mojety linked at position ...
A series of new 1,2,4-benzothiadiazine derivatives with an arylpiperazine mojety linked at position ...
A series of novel 1,2,3-benzotriazin-4-ones I (R = H, Cl, MeO, F, 3-CF3O; n = 2, 3) were prepd. and ...
The analogues 2-5 of the potent 5-HT1A receptor agonist and α1d-adrenoceptor (α1d-AR) antagonist 1 ...
In the continuing search for selective alpha(1)-adrenoceptor (AR) antagonists, new alkoxyarylpiperaz...
A series of aralkylphenoxyethylamine and aralkylmethoxyphenylpiperazine compounds was synthesized an...
We report the design and synthesis of a new class of piperazine-pyridazinone analogues. The arylpipe...
A number of 1- and 2-(4-arylpiperazinylalkyl)-4-(benzoyl)-1,2,3-triazole derivatives (1–4) were prep...
We report the design and synthesis of a new class of piperazine- pyridazinone analogues. The arylpip...
A still unknown tricyclic heterocyclic system (5) was synthesized from 6-hydroxy-2-methylpyridazin-3...
N'-Cyanoisonicotinamidine derivatives, linked to an arylpiperazine moiety, were prepared to identify...
Following our research project aimed at obtaining new compounds with high affinity and selectivity t...
We report the design and synthesis of a new class of piperazine-pyridazinone analogs. The arylpiper...
This paper reports the microwave-assisted synthesis and the binding assays on the 5-HT1A, 5-HT2A and...