Neurosteroids modulate seizure susceptibility, but their role in the regulation of epileptogenesis is unknown. Status epilepticus (SE) induces temporal lobe epileptogenesis following a latent period in which glial cells are activated. Here, we found that P450scc, the rate-limiting enzyme in steroid synthesis.. is upregulated in hippocampal glia during the latent period after pilocarpine-induced SE in rats. More prolonged SE was associated with greater P450scc expression and longer latencies to the development of seizures, suggesting that enhanced steroid synthesis retards epileptogenesis. The 5 alpha-reductase inhibitor finasteride, which blocks neurosteroid synthesis, reduced the latent period, indicating that glia-derived neurosteroids ma...
Cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) catalyzes the initial step in the b...
Neurosteroids are GABAA receptor agonists able to modulate seizure susceptibility. They are mainly s...
Neurosteroids are GABAA receptor agonists able to modulate seizure susceptibility. They are mainly s...
Neurosteroids modulate seizure susceptibility, but their role in the regulation of epileptogenesis i...
Neurosteroids modulate seizure susceptibility, but their role in the regulation of epileptogenesis i...
Neurosteroids modulate seizure susceptibility, but their role in the regulation of epileptogenesis i...
Neurosteroids modulate seizure susceptibility, but their role in the regulation of epileptogenesis i...
The conversion of cholesterol intopregnenolone by the enzyme cholesterolside-chain cleavage cytochro...
The conversion of cholesterol intopregnenolone by the enzyme cholesterolside-chain cleavage cytochro...
Epileptogenesis is defined as the latent period at the end of which spontaneous recurrent seizures o...
Epileptogenesis is defined as the latent period at the end of which spontaneous recurrent seizures o...
Epileptogenesis is defined as the latent period at the end of which spontaneous recurrent seizures o...
Epileptogenesis is defined as the latent period at the end of which spontaneous recurrent seizures o...
Purpose: The conversion of cholesterol into pregnenolone by cytochromeP450 cholesterol side-chain cl...
Purpose: The conversion of cholesterol into pregnenolone by cytochromeP450 cholesterol side-chain cl...
Cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) catalyzes the initial step in the b...
Neurosteroids are GABAA receptor agonists able to modulate seizure susceptibility. They are mainly s...
Neurosteroids are GABAA receptor agonists able to modulate seizure susceptibility. They are mainly s...
Neurosteroids modulate seizure susceptibility, but their role in the regulation of epileptogenesis i...
Neurosteroids modulate seizure susceptibility, but their role in the regulation of epileptogenesis i...
Neurosteroids modulate seizure susceptibility, but their role in the regulation of epileptogenesis i...
Neurosteroids modulate seizure susceptibility, but their role in the regulation of epileptogenesis i...
The conversion of cholesterol intopregnenolone by the enzyme cholesterolside-chain cleavage cytochro...
The conversion of cholesterol intopregnenolone by the enzyme cholesterolside-chain cleavage cytochro...
Epileptogenesis is defined as the latent period at the end of which spontaneous recurrent seizures o...
Epileptogenesis is defined as the latent period at the end of which spontaneous recurrent seizures o...
Epileptogenesis is defined as the latent period at the end of which spontaneous recurrent seizures o...
Epileptogenesis is defined as the latent period at the end of which spontaneous recurrent seizures o...
Purpose: The conversion of cholesterol into pregnenolone by cytochromeP450 cholesterol side-chain cl...
Purpose: The conversion of cholesterol into pregnenolone by cytochromeP450 cholesterol side-chain cl...
Cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) catalyzes the initial step in the b...
Neurosteroids are GABAA receptor agonists able to modulate seizure susceptibility. They are mainly s...
Neurosteroids are GABAA receptor agonists able to modulate seizure susceptibility. They are mainly s...