Add to ORKGGeometric cis, traits isomers, derivatives of 2-substituted-1,3-dioxolanes and 2-substituted-1,3-dioxanes were designed and studied as antimuscarinic agents. The synthesized compounds were evaluated as perchlorides and methiodides by functional tests with rabbit vas deferens (putative M-1), guinea-pig heart (M-2) and guinea-pig ileum (M-3). The effect of the replacement of a trimethylammonium group with a dimethylsulfonium in the two rings was also evaluated. Pharmacological results indicate that the 1,3-dioxane nucleus shows the highest stereoselective values on the studied receptors
The synthesis and antimuscarinic activity on M1, M 2 and M3 tissues of cis- and trans-2-phenyl-2-cyc...
Novel analogues of cis-N,N,N-trimethyl-(6-methyl-1,4-dioxan-2-yl)methanaminium iodide (2a) were synt...
To develop ligands that may be useful in exploring muscarinic receptor heterogeneity, we synthesized...
Geometric cis, traits isomers, derivatives of 2-substituted-1,3-dioxolanes and 2-substituted-1,3-dio...
The synthesis and antimuscarinic activity on M1, M2 and M3 tissues of a series of 2-aryl and 2-alkyl...
A series of 2-substituted 1,3-dioxolane ligands were synthesized and tested as muscarinic antagonist...
A series of new derivatives, related to diphenidol and to its 2-carbonyl analogue, were designed as ...
A series of 1,3-dioxolane-based ligands, bearing ether, thioether and related sulfoxide and sulfone ...
A series of 1,3-dioxolane-based ligands, having a lactam function were synthesized and tested as pot...
A series of rigid compounds - derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine me...
Three quaternary ammonium salts (4-6), related to muscarine and muscarone, were designed as antimusc...
A series of 1,3-dioxolane-based ligands, bearing hydroxymethyl or ester functionalities, was synthes...
The synthesis and antimuscarinic activity on M1, M 2 and M3 tissues of cis- and trans-2-phenyl-2-cyc...
Novel analogues of cis-N,N,N-trimethyl-(6-methyl-1,4-dioxan-2-yl)methanaminium iodide (2a) were synt...
To develop ligands that may be useful in exploring muscarinic receptor heterogeneity, we synthesized...
Geometric cis, traits isomers, derivatives of 2-substituted-1,3-dioxolanes and 2-substituted-1,3-dio...
The synthesis and antimuscarinic activity on M1, M2 and M3 tissues of a series of 2-aryl and 2-alkyl...
A series of 2-substituted 1,3-dioxolane ligands were synthesized and tested as muscarinic antagonist...
A series of new derivatives, related to diphenidol and to its 2-carbonyl analogue, were designed as ...
A series of 1,3-dioxolane-based ligands, bearing ether, thioether and related sulfoxide and sulfone ...
A series of 1,3-dioxolane-based ligands, having a lactam function were synthesized and tested as pot...
A series of rigid compounds - derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine me...
Three quaternary ammonium salts (4-6), related to muscarine and muscarone, were designed as antimusc...
A series of 1,3-dioxolane-based ligands, bearing hydroxymethyl or ester functionalities, was synthes...
The synthesis and antimuscarinic activity on M1, M 2 and M3 tissues of cis- and trans-2-phenyl-2-cyc...
Novel analogues of cis-N,N,N-trimethyl-(6-methyl-1,4-dioxan-2-yl)methanaminium iodide (2a) were synt...
To develop ligands that may be useful in exploring muscarinic receptor heterogeneity, we synthesized...