DnpA, a putative de-N-acetylase of the PIG-L superfamily, is required for antibiotic tolerance in Pseudomonas aeruginosa Exactly how dnpA (gene locus PA5002) directs the formation of antibiotic-tolerant persister cells is currently unknown. Previous research provided evidence for a role in surface-associated process(es), possibly in lipopolysaccharide biosynthesis. In silico sequence analysis of DnpA predicts a single transmembrane domain and Nin/Cout orientation of DnpA. In contrast, we here show that DnpA is an integral inner membrane protein containing two transmembrane domains, with the major C-terminal part located at the cytoplasmic face. Correct insertion into the inner membrane is necessary for DnpA to promote fluoroquinolone tolera...
The capacity of bacteria to survive, but not grow during antibiotic treatment may be defined as anti...
International audiencePeptidoglycan is an essential component of the bacterial cell envelope that su...
International audienceCertain Pseudomonas aeruginosa strains produce a homolog of colicin M, named P...
DnpA, a putative de-N-acetylase of the PIG-L superfamily, is required for antibiotic tolerance in Ps...
A major cause of treatment failure of infections caused by Pseudomonas aeruginosa is the presence of...
A major cause of treatment failure of infections caused by Pseudomonas aeruginosa is the presence of...
Persisters are the fraction of antibiotic-exposed bacteria transiently refractory to killing and are...
Persisters are the fraction of antibiotic-exposed bacteria transiently refractory to killing and are...
<p>Persisters are the fraction of antibiotic-exposed bacteria transiently refractory to killing and ...
Pseudomonas aeruginosa is a pathogen of high clinical relevance, responsible for many deadly infecti...
Biofilms are defined as multicellular communities encased by a self-produced extracellular matrix. I...
Pseudomonas aeruginosa is a widely found opportunistic pathogen. The emergence of multidrug-resistan...
textPseudomonas aeruginosa is a Gram-negative opportunistic pathogen often infecting the lungs of in...
Pseudomonas aeruginosa biofilms exhibit an intrinsic resistance to antibiotics and constitute a cons...
The only enzyme responsible for cadaverine production in the major multidrug-resistant human pathoge...
The capacity of bacteria to survive, but not grow during antibiotic treatment may be defined as anti...
International audiencePeptidoglycan is an essential component of the bacterial cell envelope that su...
International audienceCertain Pseudomonas aeruginosa strains produce a homolog of colicin M, named P...
DnpA, a putative de-N-acetylase of the PIG-L superfamily, is required for antibiotic tolerance in Ps...
A major cause of treatment failure of infections caused by Pseudomonas aeruginosa is the presence of...
A major cause of treatment failure of infections caused by Pseudomonas aeruginosa is the presence of...
Persisters are the fraction of antibiotic-exposed bacteria transiently refractory to killing and are...
Persisters are the fraction of antibiotic-exposed bacteria transiently refractory to killing and are...
<p>Persisters are the fraction of antibiotic-exposed bacteria transiently refractory to killing and ...
Pseudomonas aeruginosa is a pathogen of high clinical relevance, responsible for many deadly infecti...
Biofilms are defined as multicellular communities encased by a self-produced extracellular matrix. I...
Pseudomonas aeruginosa is a widely found opportunistic pathogen. The emergence of multidrug-resistan...
textPseudomonas aeruginosa is a Gram-negative opportunistic pathogen often infecting the lungs of in...
Pseudomonas aeruginosa biofilms exhibit an intrinsic resistance to antibiotics and constitute a cons...
The only enzyme responsible for cadaverine production in the major multidrug-resistant human pathoge...
The capacity of bacteria to survive, but not grow during antibiotic treatment may be defined as anti...
International audiencePeptidoglycan is an essential component of the bacterial cell envelope that su...
International audienceCertain Pseudomonas aeruginosa strains produce a homolog of colicin M, named P...