Increasing knowledge about signal transduction pathways as drivers of cancer growth has elicited the development of "targeted drugs," which inhibit aberrant signaling pathways. They require a companion diagnostic test that identifies the tumor-driving pathway; however, currently available tests like estrogen receptor (ER) protein expression for hormonal treatment of breast cancer do not reliably predict therapy response, at least in part because they do not adequately assess functional pathway activity. We describe a novel approach to predict signaling pathway activity based on knowledge-based Bayesian computational models, which interpret quantitative transcriptome data as the functional output of an active signaling pathway, by using expr...
Identifying key somatic alterations in cancer is a critical step in understanding the mechanisms tha...
Background. Breast cancer (BC) is one of the leading cause of death among females worldwide. The inc...
Recent advances in our understanding of cancer biology have led to the development of therapies targ...
Increasing knowledge about signal transduction pathways as drivers of cancer growth has elicited the...
This paper concerns a study indicating that the expression levels of genes in signaling pathways can...
BACKGROUND: Elucidating the activation pattern of molecular pathways across a given tumour type is a...
Precision treatment of cancer requires knowledge on active tumor driving signal transduction pathway...
Motivation: Gene expression measurements (microarray of RNA-seq) are affordable ways to survey cell ...
Through the use of microarray technology researchers are now able to si- multaneously measure the ex...
Predicting an individual's response to therapy is an important goal for precision medicine. Here, th...
The investigation of vulnerable components in a signaling pathway can contribute to development of d...
Abstract—Protein signaling networks play a central role in transcriptional regulation and the etiolo...
Signalling transduction pathways (STPs) are commonly hijacked by many cancers for their growth and m...
Gaining insight into the mechanisms of signal transduction networks (STNs) by using critical feature...
Genome-wide expression data can provide important insights into normal and pathological cellular pro...
Identifying key somatic alterations in cancer is a critical step in understanding the mechanisms tha...
Background. Breast cancer (BC) is one of the leading cause of death among females worldwide. The inc...
Recent advances in our understanding of cancer biology have led to the development of therapies targ...
Increasing knowledge about signal transduction pathways as drivers of cancer growth has elicited the...
This paper concerns a study indicating that the expression levels of genes in signaling pathways can...
BACKGROUND: Elucidating the activation pattern of molecular pathways across a given tumour type is a...
Precision treatment of cancer requires knowledge on active tumor driving signal transduction pathway...
Motivation: Gene expression measurements (microarray of RNA-seq) are affordable ways to survey cell ...
Through the use of microarray technology researchers are now able to si- multaneously measure the ex...
Predicting an individual's response to therapy is an important goal for precision medicine. Here, th...
The investigation of vulnerable components in a signaling pathway can contribute to development of d...
Abstract—Protein signaling networks play a central role in transcriptional regulation and the etiolo...
Signalling transduction pathways (STPs) are commonly hijacked by many cancers for their growth and m...
Gaining insight into the mechanisms of signal transduction networks (STNs) by using critical feature...
Genome-wide expression data can provide important insights into normal and pathological cellular pro...
Identifying key somatic alterations in cancer is a critical step in understanding the mechanisms tha...
Background. Breast cancer (BC) is one of the leading cause of death among females worldwide. The inc...
Recent advances in our understanding of cancer biology have led to the development of therapies targ...