Non-Phosgene Route To Unsymmetrical Ureas From N-Cbz-Α-Amino Acid Amides
- Ghazvini Zadeh, Ebrahim H.
- Abo-Dya, Nader E.
- Sotuyo, Ania C.
- Ghiviriga, Ion
- Hall, C. Dennis
DOIAbstract
A convenient method toward the synthesis of α-amino acid-derived unsymmetrical ureas 2 is described herein. This route involves an interesting rearrangement of amides of N-Cbz-α-amino acids 1, which presumably entails the intermediacy of hydantoins that is followed by hydrolysis to afford unsymmetrical ureas 2 in quantitative yields and high purity. © 2013 Elsevier Ltd. All rights reserved
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