The conversion of nicotinamide to nicotinic acid by nicotinamidase enzymes is a critical step in maintaining NAD + homeostasis and contributes to numerous important biological processes in diverse organisms. In Borrelia burgdorferi, the nicotinamidase enzyme, PncA, is required for spirochaete survival throughout the infectious cycle. Mammals lack nicotinamidases and therefore PncA may serve as a therapeutic target for Lyme disease. Contrary to the in vivo importance of PncA, the current annotation for the pncA ORF suggests that the encoded protein may be inactive due to the absence of an N-terminal aspartic acid residue that is a conserved member of the catalytic triad of characterized PncA proteins. Herein, we have used genetic and biochem...
ABSTRACT Borrelia burgdorferi, the pathogen of Lyme disease, encodes many conserved proteins of unkn...
Analysis of the transcriptome of Borrelia burgdorferi, the causative agent of Lyme disease, during i...
Borrelia burgdorferisensu lato, the causative agent of tick-borne Lyme borreliosis (LB), has a limit...
The conversion of nicotinamide to nicotinic acid by nicotinamidase enzymes is a critical step in mai...
The conversion of nicotinamide to nicotinic acid by nicotinamidase enzymes is a critical step in mai...
Borrelia burgdorferi, a spirochete and the causative agent of Lyme disease, infects both mammals and...
The bacterium Borrelia burgdorferi is the causative agent of Lyme disease, the most common arthropod...
Nelson*1 Background: The bacterium Borrelia burgdorferi, the causative agent of Lyme disease, is a l...
The post-translational modification of proteins has been shown to be extremely important in prokaryo...
The bacterium Borrelia burgdorferi is the causative agent of Lyme disease, the most common arthropod...
Lyme disease, the most common tick borne disease in United States, is caused by the bacterial pathog...
The genome of Borrelia burgdorferi encodes a set of genes putatively involved in cyclic-di-GMP metab...
The post-translational modification of proteins has been shown to be extremely important in prokaryo...
The post-translational modification of proteins has been shown to be extremely important in prokaryo...
Publisher Copyright: © 2023 The AuthorsATP-dependent proteases FtsH are conserved in bacteria, mitoc...
ABSTRACT Borrelia burgdorferi, the pathogen of Lyme disease, encodes many conserved proteins of unkn...
Analysis of the transcriptome of Borrelia burgdorferi, the causative agent of Lyme disease, during i...
Borrelia burgdorferisensu lato, the causative agent of tick-borne Lyme borreliosis (LB), has a limit...
The conversion of nicotinamide to nicotinic acid by nicotinamidase enzymes is a critical step in mai...
The conversion of nicotinamide to nicotinic acid by nicotinamidase enzymes is a critical step in mai...
Borrelia burgdorferi, a spirochete and the causative agent of Lyme disease, infects both mammals and...
The bacterium Borrelia burgdorferi is the causative agent of Lyme disease, the most common arthropod...
Nelson*1 Background: The bacterium Borrelia burgdorferi, the causative agent of Lyme disease, is a l...
The post-translational modification of proteins has been shown to be extremely important in prokaryo...
The bacterium Borrelia burgdorferi is the causative agent of Lyme disease, the most common arthropod...
Lyme disease, the most common tick borne disease in United States, is caused by the bacterial pathog...
The genome of Borrelia burgdorferi encodes a set of genes putatively involved in cyclic-di-GMP metab...
The post-translational modification of proteins has been shown to be extremely important in prokaryo...
The post-translational modification of proteins has been shown to be extremely important in prokaryo...
Publisher Copyright: © 2023 The AuthorsATP-dependent proteases FtsH are conserved in bacteria, mitoc...
ABSTRACT Borrelia burgdorferi, the pathogen of Lyme disease, encodes many conserved proteins of unkn...
Analysis of the transcriptome of Borrelia burgdorferi, the causative agent of Lyme disease, during i...
Borrelia burgdorferisensu lato, the causative agent of tick-borne Lyme borreliosis (LB), has a limit...