The growth hormone receptor knockout (GHRKO) mice are remarkably long-lived and highly insulin sensitive. Alterations in mitochondrial biogenesis are associated with aging and various metabolic derangements. We have previously demonstrated increased gene expression of key regulators of mitochondriogenesis in kidneys, hearts and skeletal muscles of GHRKO mice. The aim of the present study was to quantify the protein levels of the following regulators of mitochondriogenesis: peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α), AMP-activated protein kinase α (AMPKα), phospho-AMPKα (p-AMPKα), sirtuin-3 (SIRT-3), endothelial nitric oxide synthase (eNOS), phospho-eNOS (p-eNOS), nuclear respiratory factor-1 (NRF-1) and mitofusin-...
Background: Aberrant skeletal muscle mitochondrial oxidative metabolism is a debilitating feature of...
Growth hormone (GH) exerts diverse tissue-specific metabolic effects that are not revealed by global...
In both rodents and humans, aging-associated reductions in skeletal muscle AMP-activated protein kin...
The growth hormone receptor knockout (GHRKO) mice are remarkably long-lived and highly insulin sensi...
The growth hormone receptor knockout (GHRKO) mice are remarkably long-lived and highly insulin sensi...
Decreased somatotrophic signaling is among the most important mechanisms associated with extended lo...
Decreased somatotrophic signaling is among the most important mechanisms associated with extended lo...
Despite increased longevity and resistance to multiple stressors, growth hormone receptor null (GHRK...
mTOR is a serine/threonine kinase that binds with multiple proteins to form two complexes, mTORC1 an...
International audienceCalorie restriction (CR) is a dietary intervention that extends lifespan and h...
Most mutations that delay aging and prolong lifespan in the mouse are related to somatotropic and/or...
Most mutations that delay aging and prolong lifespan in the mouse are related to somatotropic and/or...
Objective: PGC-1α is a transcriptional co-activator and master regulator of mitochondrial biogenesis...
Growth hormone receptor-deficient (GHRKO) mice are long-lived and have reduced insulin-like growth f...
Although it is well established that physical activity increases mitochondrial content in muscle, th...
Background: Aberrant skeletal muscle mitochondrial oxidative metabolism is a debilitating feature of...
Growth hormone (GH) exerts diverse tissue-specific metabolic effects that are not revealed by global...
In both rodents and humans, aging-associated reductions in skeletal muscle AMP-activated protein kin...
The growth hormone receptor knockout (GHRKO) mice are remarkably long-lived and highly insulin sensi...
The growth hormone receptor knockout (GHRKO) mice are remarkably long-lived and highly insulin sensi...
Decreased somatotrophic signaling is among the most important mechanisms associated with extended lo...
Decreased somatotrophic signaling is among the most important mechanisms associated with extended lo...
Despite increased longevity and resistance to multiple stressors, growth hormone receptor null (GHRK...
mTOR is a serine/threonine kinase that binds with multiple proteins to form two complexes, mTORC1 an...
International audienceCalorie restriction (CR) is a dietary intervention that extends lifespan and h...
Most mutations that delay aging and prolong lifespan in the mouse are related to somatotropic and/or...
Most mutations that delay aging and prolong lifespan in the mouse are related to somatotropic and/or...
Objective: PGC-1α is a transcriptional co-activator and master regulator of mitochondrial biogenesis...
Growth hormone receptor-deficient (GHRKO) mice are long-lived and have reduced insulin-like growth f...
Although it is well established that physical activity increases mitochondrial content in muscle, th...
Background: Aberrant skeletal muscle mitochondrial oxidative metabolism is a debilitating feature of...
Growth hormone (GH) exerts diverse tissue-specific metabolic effects that are not revealed by global...
In both rodents and humans, aging-associated reductions in skeletal muscle AMP-activated protein kin...