Molecular studies have shown that the majority of azole resistance in Aspergillus fumigatus is associated with amino acid substitutions in the cyp51A gene. To obtain insight into azole resistance mutations, the cyp51A gene of 130 resistant and 76 susceptible A. fumigatus isolates was sequenced. Out of 130 azole-resistant isolates, 105 contained a tandem repeat of 34 bp in the promoter region and a leucine-to-histidine substitution in codon 98 (designated TR/L98H). Additionally, in 12 of these TR/L98H resistant isolates, the mutations S297T and F495I were found, and in 1 isolate, the mutation F495I was found. In eight azole-resistant isolates, known azole resistance mutations were detected in codon G54, G138, or M220. In three azole-suscepti...
Item does not contain fulltextAspergillus fumigatus, a ubiquitously distributed opportunistic pathog...
Aspergillus fumigatus, a ubiquitously distributed opportunistic pathogen, is the global leading caus...
A rapid and global emergence of azole resistance has been observed in the pathogenic fungus Aspergil...
Molecular studies have shown that the majority of azole resistance in Aspergillus fumigatus is assoc...
Contains fulltext : 88470.pdf (publisher's version ) (Open Access)Molecular studie...
Since 1998, the rapid emergence of multi-azole-resistance (MAR) was observed in Aspergillus fumigatu...
Item does not contain fulltextNine consecutive isogenic Aspergillus fumigatus isolates cultured from...
Nine consecutive isogenic Aspergillus fumigatus isolates cultured from a patient with aspergilloma w...
Azole compounds are the primary therapy for patients with diseases caused by Aspergillus fumigatus. ...
The Aspergillus fumigatus cyp51A gene TR46/Y121F/T289A mutation is a new emerging resistance mechani...
Azole compounds are the primary therapy for patients with diseases caused by Aspergillus fumigatus. ...
Azole compounds are the primary therapy for patients with diseases caused by Aspergillus fumigatus. ...
AIM: The main goal of the present study was to find azole-resistant and molecular analysis of cyp51A...
Aspergillus fumigatus is a commonly encountered fungus in the environment and has a primary ecologic...
Azoles are the mainstay of oral therapy for aspergillosis. Azole resistance in Aspergillus has been ...
Item does not contain fulltextAspergillus fumigatus, a ubiquitously distributed opportunistic pathog...
Aspergillus fumigatus, a ubiquitously distributed opportunistic pathogen, is the global leading caus...
A rapid and global emergence of azole resistance has been observed in the pathogenic fungus Aspergil...
Molecular studies have shown that the majority of azole resistance in Aspergillus fumigatus is assoc...
Contains fulltext : 88470.pdf (publisher's version ) (Open Access)Molecular studie...
Since 1998, the rapid emergence of multi-azole-resistance (MAR) was observed in Aspergillus fumigatu...
Item does not contain fulltextNine consecutive isogenic Aspergillus fumigatus isolates cultured from...
Nine consecutive isogenic Aspergillus fumigatus isolates cultured from a patient with aspergilloma w...
Azole compounds are the primary therapy for patients with diseases caused by Aspergillus fumigatus. ...
The Aspergillus fumigatus cyp51A gene TR46/Y121F/T289A mutation is a new emerging resistance mechani...
Azole compounds are the primary therapy for patients with diseases caused by Aspergillus fumigatus. ...
Azole compounds are the primary therapy for patients with diseases caused by Aspergillus fumigatus. ...
AIM: The main goal of the present study was to find azole-resistant and molecular analysis of cyp51A...
Aspergillus fumigatus is a commonly encountered fungus in the environment and has a primary ecologic...
Azoles are the mainstay of oral therapy for aspergillosis. Azole resistance in Aspergillus has been ...
Item does not contain fulltextAspergillus fumigatus, a ubiquitously distributed opportunistic pathog...
Aspergillus fumigatus, a ubiquitously distributed opportunistic pathogen, is the global leading caus...
A rapid and global emergence of azole resistance has been observed in the pathogenic fungus Aspergil...