MRI-based delta-radiomics predicts pathologic complete response in high-grade soft-tissue sarcoma patients treated with neoadjuvant therapy
- Peeken, J.C.
- Asadpour, R.
- Specht, K.
- Chen, E.Y.
- Klymenko, O.
- Akinkuoroye, V.
- Hippe, D.S.
- Spraker, M.B.
- Schaub, S.K.
- Dapper, H.
- Knebel, C.
- Mayr, N.A.
- Gersing, A.S.
- Woodruff, H.C.
- Lambin, P.
- Nyflot, M.J.
- Combs, S.E.
DOIAbstract
Purpose: In high-grade soft-tissue sarcomas (STS) the standard of care encompasses multimodal therapy regimens. While there is a growing body of evidence for prognostic pretreatment radiomic models, we hypothesized that temporal changes in radiomic features following neoadjuvant treatment ("delta-radio mics") may be able to predict the pathological complete response (pCR). Methods: MRI scans (T1-weighted with fat-saturation and contrast-enhancement (T1FSGd) and T2 weighted with fat-saturation (T2FS)) of patients with STS of the extremities and trunk treated with neoadjuvant therapy were gathered from two independent institutions (training: 103, external testing: 53 patients). pCR was defined as <5% viable cells. After segmentation and prepr...
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