Cerebellar volume is highly heritable and associated with neurodevelopmental and neurodegenerative disorders. Understanding the genetic architecture of cerebellar volume may improve our insight into these disorders. This study aims to investigate the convergence of cerebellar volume genetic associations in close detail. A genome-wide associations study for cerebellar volume was performed in a discovery sample of 27,486 individuals from UK Biobank, resulting in 30 genome-wide significant loci and a SNP heritability of 39.82%. We pinpoint the likely causal variants and those that have effects on amino acid sequence or cerebellar gene-expression. Additionally, 85 genome-wide significant genes were detected and tested for convergence onto biolo...
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identi...
International audienceSubcortical brain structures are integral to motion, consciousness, emotions a...
Intracranial volume reflects the maximally attained brain size during development, and remains stabl...
Cerebellar volume is highly heritable and associated with neurodevelopmental and neurodegenerative d...
Interest in the cerebellum is expanding given evidence of its contributions to cognition and emotion...
Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide associat...
The genetic architecture of brain structure and function is largely unknown. To investigate this, we...
Contains fulltext : 165723pub.pdf (publisher's version ) (Closed access)Intracrani...
The genetic basis of brain structure and function is largely unknown. We carried out genome-wide ass...
Individual variations of white matter (WM) tracts are known to be associated with various cognitive ...
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identi...
International audienceSubcortical brain structures are integral to motion, consciousness, emotions a...
Intracranial volume reflects the maximally attained brain size during development, and remains stabl...
Cerebellar volume is highly heritable and associated with neurodevelopmental and neurodegenerative d...
Interest in the cerebellum is expanding given evidence of its contributions to cognition and emotion...
Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide associat...
The genetic architecture of brain structure and function is largely unknown. To investigate this, we...
Contains fulltext : 165723pub.pdf (publisher's version ) (Closed access)Intracrani...
The genetic basis of brain structure and function is largely unknown. We carried out genome-wide ass...
Individual variations of white matter (WM) tracts are known to be associated with various cognitive ...
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identi...
International audienceSubcortical brain structures are integral to motion, consciousness, emotions a...
Intracranial volume reflects the maximally attained brain size during development, and remains stabl...