Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022
- Eggink, Dirk
- Andeweg, Stijn P.
- Vennema, Harry
- van Maarseveen, Noortje
- Vermaas, Klaas
- Vlaemynck, Boris
- Schepers, Raf
- van Gageldonk-Lafeber, Arianne B.
- van den Hof, Susan
- Reusken, Chantal B. E. M.
- Knol, Mirjam J.
Publication date
January 2022
DOI Publisher
European Centre for Disease Control and Prevention (ECDC)Abstract
Infections with the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 174,349 SARSCoV-2-infected individuals (≥12 years), we observed an increased risk of S gene target failure, predictive of the Omicron variant, in vaccinated (odds ratio (OR): 3.6; 95% confidence interval (CI): 3.4–3.7) and previously infected individuals (OR: 4.2; 95% CI: 3.8–4.7) compared with infected naïve individuals. This suggests vaccine- or infection-induced immunity against SARS-CoV-2 infections is less effective against the Omicron than the Delta variant
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