Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease
- Desikan, RS
- Schork, AJ
- Wang, Yongyi
- Thompson, WK
- Dehghan, Abbas
- Ridker, PM
- Chasman, DI
- McEvoy, LK
- Holland, D
- Chen, CH
- Karow, DS
- Brewer, JB
- Hess, CP
- Williams, J
- Sims, R
- O'Donovan, MC
- Choi, SH
- Bis, JC
- Ikram, Arfan
- Gudnason, V
- DeStefano, AL
- van der Lee, Sven
- Psaty, BM
- Duijn, Cornelia
- Launer, L
- Seshadri, S
- Pericak-Vance, MA
- Mayeux, R
- Haines, JL
- Farrer, LA
- Hardy, J
- Ulstein, ID
- Aarsland, D
- Fladby, T
- White, LR
- Sando, SB
- Rongve, A
- Witoelar, A
- Djurovic, S
- Hyman, BT
- Snaedal, J
- Steinberg, S
- Stefansson, H
- Stefansson, K
- Schellenberg, GD
- Andreassen, OA
- Dale, AM
DOIAbstract
Background-Epidemiological findings suggest a relationship between Alzheimer disease (AD), inflammation, and dyslipidemia, although the nature of this relationship is not well understood. We investigated whether this phenotypic association arises from a shared genetic basis. Methods and Results-Using summary statistics (P values and odds ratios) from genome-wide association studies of >200 000 individuals, we investigated overlap in single-nucleotide polymorphisms associated with clinically diagnosed AD and C-reactive protein (CRP), triglycerides, and high-and low-density lipoprotein levels. We found up to 50-fold enrichment of AD single-nucleotide polymorphisms for different levels of association with C-reactive protein, low-density lipopr...
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