Tuberous sclerosis complex (TSC) is an autosomal dominant, multisystem disorder caused by mutations in either the TSC1 or TSC2 genes and characterized by developmental brain abnormalities. In the present study we discuss the neuropathological findings of a 32-year-old patient with a germ-line mutation in the TSC2 gene. Post mortem MRI combined with histology and immunocytochemical analysis was applied to demonstrate widespread anatomical abnormalities of gray and white matter structure. TSC brain lesions were analyzed for loss of heterozygosity (LOH) on chromosome 16p13. The neuropathological supratentorial abnormalities were represented by multiple subependymal nodules (SENs) and cortical tubers. In addition to cerebral cortical lesions, c...
Objective: The purpose of this study was to systematically analyze the associations between differen...
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the development ...
Background: Tuberous sclerosis complex (TSC) is a multisystem disorder that results from mutations i...
Tuberous sclerosis complex (TSC) is an autosomal dominant, multisystem disorder caused by mutations ...
<div><p>Tuberous Sclerosis Complex (TSC) is a genetic hamartoma syndrome frequently associated with ...
Tuberous Sclerosis Complex (TSC) is a genetic hamartoma syndrome frequently associated with severe i...
Objective To investigate the clinicopathological and molecular genetic features of cortical tubers i...
To study the clinicopathologic features of tuberous sclerosis complex (TSC).The clinicopathologic da...
Tuberous Sclerosis Complex (TSC) is a multisystem genetic disorder characterized by hamartomatous le...
Tuberous sclerosis (also known as tuberous sclerosis complex [TSC]) is a multisystem genetic disorde...
Tuberous sclerosis complex (TSC) represents the prototypic monogenic disorder of the mammalian targe...
Structural brain malformations associated with Tuberous Sclerosis Complex (TSC) are related to the s...
Two genes, mutations in which result in the phenotype of tuberous sclerosis (TSC), have recently bee...
Background Tuberous sclerosis complex (TSC) is a multisystem disorder that results from mutations...
Objective: The purpose of this study was to systematically analyze the associations between differen...
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the development ...
Background: Tuberous sclerosis complex (TSC) is a multisystem disorder that results from mutations i...
Tuberous sclerosis complex (TSC) is an autosomal dominant, multisystem disorder caused by mutations ...
<div><p>Tuberous Sclerosis Complex (TSC) is a genetic hamartoma syndrome frequently associated with ...
Tuberous Sclerosis Complex (TSC) is a genetic hamartoma syndrome frequently associated with severe i...
Objective To investigate the clinicopathological and molecular genetic features of cortical tubers i...
To study the clinicopathologic features of tuberous sclerosis complex (TSC).The clinicopathologic da...
Tuberous Sclerosis Complex (TSC) is a multisystem genetic disorder characterized by hamartomatous le...
Tuberous sclerosis (also known as tuberous sclerosis complex [TSC]) is a multisystem genetic disorde...
Tuberous sclerosis complex (TSC) represents the prototypic monogenic disorder of the mammalian targe...
Structural brain malformations associated with Tuberous Sclerosis Complex (TSC) are related to the s...
Two genes, mutations in which result in the phenotype of tuberous sclerosis (TSC), have recently bee...
Background Tuberous sclerosis complex (TSC) is a multisystem disorder that results from mutations...
Objective: The purpose of this study was to systematically analyze the associations between differen...
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the development ...
Background: Tuberous sclerosis complex (TSC) is a multisystem disorder that results from mutations i...