A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study
- Papadimitriou, Nikos
- Muller, David
- van den Brandt, Piet A.
- Geybels, Milan
- Patel, Chirag J.
- Gunter, Marc J.
- Lopez, David S.
- Key, Timothy J.
- Perez-Cornago, Aurora
- Ferrari, Pietro
- Vineis, Paolo
- Weiderpass, Elisabete
- Boeing, Heiner
- Agudo, Antonio
- Sanchez, Maria-Jose
- Overvad, Kim
- Kuehn, Tilman
- Fortner, Renee T.
- Palli, Domenico
- Drake, Isabel
- Bjartell, Anders
- Santiuste, Carmen
- Bueno-de-Mesquita, Bas H.
- Krogh, Vittorio
- Tjonneland, Anne
- Lauritzen, Dorthe Furstrand
- Gurrea, Aurelio Barricarte
- Quiros, Jose Ramon
- Stattin, Par
- Trichopoulou, Antonia
- Martimianaki, Georgia
- Karakatsani, Anna
- Thysell, Elin
- Johansson, Ingegerd
- Ricceri, Fulvio
- Tumino, Rosario
- Larranaga, Nerea
- Khaw, Kay Tee
- Riboli, Elio
- Tzoulaki, Ioanna
- Tsilidis, Konstantinos K.
DOIAbstract
Purpose The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. Methods A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery ra...
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