The consequences of chronic infection with the HCV on immunity to distinct pathogens are not fully appreciated, despite the potent modulatory effects of HCV on the immune system. We observed that upon TLR4 ligation, monocytes from chronic HCV patients demonstrated three to five times lower TNF and IL-12p40 production as compared with healthy individuals. However, augmented production of TNF, IL-12p40, and IL-12p70 by monocytes was observed upon stimulation with R848. Importantly, we observed that the levels of IL-10 in chronic HCV patients are higher in serum and that more IL-10 is produced by monocytes as compared with healthy individuals. The inhibitory effect of IL-10 on the production of proinflammatory cytokines by monocytes was only o...
Antiviral immunity requires recognition of viral pathogens and activation of cytotoxic and Th cells ...
Insufficient elimination of the hepatitis C virus (HCV) during acute infection results in chronic di...
Recent studies reveal the accumulation of myeloid derived suppressor cells (MDSCs) in human peripher...
impairment of monocytes upon TLR4 ligation in patients with chronic HCV infection
BACKGROUND and AIMS: Persistent inflammation contributes to progression of liver damage in chronic H...
Chronic hepatitis C virus (HCV) infection is associated with weak CD4+ T-helper type 1 reactivity an...
This study investigated the influence of Hepatitis C virus (HCV) infection on the cytokine productio...
Little is known about the frequency and function of CD16(+)CD14(-) monocytes from chronic HCV patien...
IFN-alpha production by plasmacytoid dendritic cells (PDCs) is critical in antiviral immunity. In th...
Hepatitis C virus (HCV) dysregulates innate immune responses and induces persistent viral infection....
textabstractHepatitis C virus (HCV) establishes persistent infection in about 80% of the infected in...
BACKGROUND: Lack of protective antibodies and inefficient cytotoxic responses are characteristics of...
Hepatitis C virus (HCV) is remarkably efficient at evading host immunity to establish chronic infect...
Although in vitro studies have been performed to dissect the mechanism of action of IFN alpha, detai...
AIM: Hepatitis C virus often establishes chronic infections. Recent studies suggest that viral and b...
Antiviral immunity requires recognition of viral pathogens and activation of cytotoxic and Th cells ...
Insufficient elimination of the hepatitis C virus (HCV) during acute infection results in chronic di...
Recent studies reveal the accumulation of myeloid derived suppressor cells (MDSCs) in human peripher...
impairment of monocytes upon TLR4 ligation in patients with chronic HCV infection
BACKGROUND and AIMS: Persistent inflammation contributes to progression of liver damage in chronic H...
Chronic hepatitis C virus (HCV) infection is associated with weak CD4+ T-helper type 1 reactivity an...
This study investigated the influence of Hepatitis C virus (HCV) infection on the cytokine productio...
Little is known about the frequency and function of CD16(+)CD14(-) monocytes from chronic HCV patien...
IFN-alpha production by plasmacytoid dendritic cells (PDCs) is critical in antiviral immunity. In th...
Hepatitis C virus (HCV) dysregulates innate immune responses and induces persistent viral infection....
textabstractHepatitis C virus (HCV) establishes persistent infection in about 80% of the infected in...
BACKGROUND: Lack of protective antibodies and inefficient cytotoxic responses are characteristics of...
Hepatitis C virus (HCV) is remarkably efficient at evading host immunity to establish chronic infect...
Although in vitro studies have been performed to dissect the mechanism of action of IFN alpha, detai...
AIM: Hepatitis C virus often establishes chronic infections. Recent studies suggest that viral and b...
Antiviral immunity requires recognition of viral pathogens and activation of cytotoxic and Th cells ...
Insufficient elimination of the hepatitis C virus (HCV) during acute infection results in chronic di...
Recent studies reveal the accumulation of myeloid derived suppressor cells (MDSCs) in human peripher...