Epidemiological Applications in -Omics Approaches

For -omics investigations to achieve their aspired potential, fundamental aspects relating to the study design and statistical analyses in clinical -omics investigations must be dully addressed. The present chapter addresses the most appropriate epidemiological study designs for assessing diagnostic and prognostic biomarkers including cross-sectional, case-control, and cohort studies. Modes of their optimal implementation, as well as potential pitfalls, are detailed. Finally, statistical approaches for evaluating the utility of diagnostic and prognostic biomarkers are also discussed