What Do We Know about Survival in Skeletally Premature Children Aged 0 to 10 Years with Ewing Sarcoma? A Multicenter 10-Year Follow-Up Study in 60 Patients

Bosma, S.E.
Heijden, L. van der
Sierrasesumaga, L.
Merks, H.J.H.M.
Haveman, L.M.
Sande, M.A.J. van de
San-Julian, M.

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Publication date

March 2022

DOI

10.3390/cancers14061456

Publisher

MDPI AG

Abstract

Simple Summary Younger age has been associated with better overall survival in Ewing sarcoma, especially under the age of 10. Our study aimed at describing long-term outcomes of a cohort of 60 patients aged 0-10 with Ewing sarcoma, treated with chemotherapy, surgery and/or radiotherapy. Overall survival of these youngest patients with ES was very good. After 10 years, 81% of patients were still alive, 89% did not have a local recurrence and 81% did not have distant metastasis (in lungs and/or bone). Limb salvage surgery was achieved in >90% of patients. Wide resection margin was the only factor significantly associated with better survival, but age 90% of patients. Wide resection margin was the only factor significantly associated with bett...