Severity of Bronchopulmonary Dysplasia and Neurodevelopmental Outcome at 2 and 5 Years Corrected Age
- Katz, Trixie A.
- Vliegenthart, Roseanne J. S.
- Aarnoudse-Moens, Cornelieke S. H.
- Leemhuis, Aleid G.
- Beuger, Sabine
- Blok, Geert Jan
- van Brakel, Monique J. M.
- van den Heuvel, Maria E. N.
- van Kempen, Anne A. M. W.
- Lutterman, Claire
- Rijpert, Maarten
- Schiering, Irene A.
- Ran, Nicolien C.
- Visser, Fenna
- Wilms, Janneke
- van Kaam, Anton H.
- Onland, Wes
DOIAbstract
Objective: To evaluate the association between bronchopulmonary dysplasia (BPD) severity and risk of neurodevelopmental impairment (NDI) at 2 years and 5 years corrected age and to examine whether this association changes over time. Study design: This single-center retrospective cohort study included patients with a gestational age <30 weeks surviving to 36 weeks postmenstrual age, divided into groups according to BPD severity. NDI was defined as having cognitive or motor abilities below −1 SD, cerebral palsy, or a hearing or a visual impairment. The association was assessed using a multivariate logistic regression model analysis, adjusting for known confounders for NDI, and mixed-model analysis. Results: Of the 790 surviving infants (15% d...
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