The aim of this study was to develop a population pharmacokinetic model of sufentanil and to assess the influence of covariates in critically ill children admitted to a pediatric intensive care unit. After institutional approval, 41 children were enrolled in the study. Blood samples for pharmacokinetic (PK) assessment were collected from routinely placed arterial catheters during and after discontinuation of infusion. Population nonlinear mixed-effects modeling was performed using NONMEM. A 2-compartment model described sufentanil PK sufficiently. Typical values of the central and peripheral volume of distribution and the metabolic and intercompartmental clearance for a theoretical patient weighing 70kg were V-C=7.90 l, V-T=481L, Cl=45.3L/h...
Severe malnutrition in children remains a global health problem. The pharmacokinetics of drugs are a...
Background: To study propofol pharmacodynamics in a clinical setting a pharmacokinetic model must be...
Purpose: The aim of the present study was to develop a population pharmacokinetic model of midazolam...
BACKGROUND: S-ketamine is the S(+)-enantiomer of the racemic mixture ketamine, an anesthetic drug pr...
Background Target-controlled infusion (TCI) has been recently developed and successfully implemented...
Background Sufentanil is a suitable choice for target-controlled infusion (TCI) because of its short...
The objective was to study the population pharmacokinetics of bound and unbound phenytoin in critica...
The objective was to study the population pharmacokinetics of bound and unbound phenytoin in critica...
Fentanyl is widely used for analgesia, sedation, and anesthesia both in adult and pediatric populat...
Background. Predictive performance of eleven published propofol pharmacokinetic models was evaluated...
Target controlled infusion (TCI) is a clinically-available and widely-used computer-controlled metho...
BACKGROUND: Cefotaxime is frequently used in critically ill children, however pharmacokinetic (PK) s...
Target controlled infusion (TCI) is a clinically-available and widely-used computer-controlled metho...
Background: To study propofol pharmacodynamics in a clinical setting a pharmacokinetic model must be...
Background: Pharmacokinetic and pharmacodynamic models are used to predict and explore drug infusion...
Severe malnutrition in children remains a global health problem. The pharmacokinetics of drugs are a...
Background: To study propofol pharmacodynamics in a clinical setting a pharmacokinetic model must be...
Purpose: The aim of the present study was to develop a population pharmacokinetic model of midazolam...
BACKGROUND: S-ketamine is the S(+)-enantiomer of the racemic mixture ketamine, an anesthetic drug pr...
Background Target-controlled infusion (TCI) has been recently developed and successfully implemented...
Background Sufentanil is a suitable choice for target-controlled infusion (TCI) because of its short...
The objective was to study the population pharmacokinetics of bound and unbound phenytoin in critica...
The objective was to study the population pharmacokinetics of bound and unbound phenytoin in critica...
Fentanyl is widely used for analgesia, sedation, and anesthesia both in adult and pediatric populat...
Background. Predictive performance of eleven published propofol pharmacokinetic models was evaluated...
Target controlled infusion (TCI) is a clinically-available and widely-used computer-controlled metho...
BACKGROUND: Cefotaxime is frequently used in critically ill children, however pharmacokinetic (PK) s...
Target controlled infusion (TCI) is a clinically-available and widely-used computer-controlled metho...
Background: To study propofol pharmacodynamics in a clinical setting a pharmacokinetic model must be...
Background: Pharmacokinetic and pharmacodynamic models are used to predict and explore drug infusion...
Severe malnutrition in children remains a global health problem. The pharmacokinetics of drugs are a...
Background: To study propofol pharmacodynamics in a clinical setting a pharmacokinetic model must be...
Purpose: The aim of the present study was to develop a population pharmacokinetic model of midazolam...