Adrenal Medullary Hyperplasia Is a Precursor Lesion for Pheochromocytoma in MEN2 Syndrome
- Korpershoek, Esther
- Petri, Bart-Jeroen
- Post, Edward
- van Eijck, Casper
- Oldenburg, Rogier
- Belt, Eric
- de Herder, W.W.
- de Krijger, Ronald
- Dinjens, Winand
DOIAbstract
Adrenal medullary hyperplasias (AMHs) are adrenal medullary proliferations with a size <1 cm, while larger lesions are considered as pheochromocytoma (PCC). This arbitrary distinction has been proposed decades ago, although the biological relationship between AMH and PCC has never been investigated. Both lesions are frequently diagnosed in multiple endocrine neoplasia type 2 (MEN2) patients in whom they are considered as two unrelated clinical entities. In this study, we investigated the molecular relationship between AMH and PCC in MEN2 patients. Molecular aberrations of 19 AMHs and 13 PCCs from 18 MEN2 patients were determined by rearranged during transfection (RET) proto-oncogene mutation analysis and loss of heterozygosity (LOH) analysi...
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