15-Year Follow-up of a Multicenter, Randomized, Calcineurin Inhibitor Withdrawal Study in Kidney Transplantation
- Roodnat, J.I.
- Hilbrands, LB
- Hene, RJ
- de Sevaux, RGL
- Gregoor, PJHS
- Kal - van Gestel, Judith
- Konijn, C
- van Zuilen, A
- Gelder, Teun
- Hoitsma, AJ
- Weimar, Willem
DOIAbstract
Background. Calcineurin inhibitors (CNIs) are essential immunosuppressive drugs after renal transplantation. Because of nephrotoxicity, withdrawal has been a challenge since their introduction. Methods. A randomized multicenter trial included 212 kidney patients transplanted between 1997 and 1999. All patients were initially treated with mycophenolate mofetil (MMF), cyclosporine A (CsA), and prednisone (pred). At 6 months after transplantation, 63 patients were randomized for MMF/pred, 76 for MMF/CsA, and 73 for MMF/CsA/pred. Within 18 months after randomization 23 patients experienced a rejection episode: MMF/pred (27.0%), MMF/CsA (6.8%) and MMF/CsA/pred (1.4%) (P<0.001). Results. During 15 years of follow-up, 73 patients died with a funct...
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