Genome-wide association study of intracranial aneurysm identifies three new risk loci
- Yasuno, K
- Bilguvar, K
- Bijlenga, P
- Low, SK
- Krischek, B
- Auburger, G
- Simon, M
- Krex, D
- Arlier, Z
- Nayak, N
- Ruigrok, YM
- Niemelaa, M
- Tajima, A
- Fraunberg, MVZ
- Doczi, T
- Wirjatijasa, F
- Hata, A
- Blasco, J
- Oszvald, A
- Kasuya, H
- Zilani, G
- Schoch, B
- Singh, P
- Stuer, C
- Risselada, Roelof
- Beck, J
- Sola, T
- Ricciardi, F
- Aromaa, A
- Illig, T
- Schreiber, S
- Duijn, Cornelia
- van den Berg, LH
- Perret, C
- Proust, C
- Roder, CH
- Ozturk, AK
- Gaal, E
- van den Berg, D
- Geisen, C
- Friedrich, CM
- Summers, P
- Frangi, AF
- State, MW
- Wichmann, HE
- Breteler, Monique
- Wijmenga, C
- Mane, S
- Peltonen, L
- Elio, V
- Sturkenboom, MCJM
- Lawford, P
- Byrne, J
- Macho, J
- Sandalcioglu, EI
- Meyer, B
- Raabe, A
- Steinmetz, H
- Rufenacht, D
- Jaaskelainen, JE
- Hernesniemi, J
- Rinkel, GJE
- Zembutsu, H
- Inoue, I
- Palotie, A
- Cambien, F
- Nakamura, Y
- Lifton, RP
- Gunel, M
DOIAbstract
Saccular intracranial aneurysms are balloon-like dilations of the intracranial arterial wall; their hemorrhage commonly results in severe neurologic impairment and death. We report a second genome-wide association study with discovery and replication cohorts from Europe and Japan comprising 5,891 cases and 14,181 controls with similar to 832,000 genotyped and imputed SNPs across discovery cohorts. We identified three new loci showing strong evidence for association with intracranial aneurysms in the combined dataset, including intervals near RBBP8 on 18q11.2 (odds ratio (OR) = 1.22, P = 1.1 x 10(-12)), STARD13-KL on 13q13.1 (OR = 1.20, P = 2.5 x 10(-9)) and a gene-rich region on 10q24.32 (OR = 1.29, P = 1.2 x 10(-9)). We also confirmed prio...
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