Cathepsin K is a cysteine proteinase expressed predominantly in osteoclasts. Cathepsin K cleaves key bone matrix proteins and is believed to play an important role in degrading the organic phase of bone during bone resorption. Pycnodysostosis, an autosomal recessive osteosclerosing skeletal disorder has recently been shown to result from mutations in the cathepsin K gene. Cathepsin K deficient mice generated by targeted disruption of this proteinase phenocopy many aspects of pycnodysostosis. They display an osteopetrotic phenotype with excessive trabeculation of the bone-marrow space accompanied by an altered ultrastructural appearance of the cathepsin K deficient osteoclasts. These cells also demonstrate an impaired resorptive activity in ...
Summary: Osteoclast research has an exciting history and a challenging future. More than 3 decades a...
Background The process of bone resorption by osteoclasts is regulated by Cathepsin K, the lysosomal ...
BACKGROUND: The process of bone resorption by osteoclasts is regulated by Cathepsin K, the lysosomal...
Osteoclastic bone degradation involves the activity of cathepsin K. We found that in addition to thi...
Osteoclastic bone degradation involves the activity of cathepsin K. We found that in addition to thi...
Objective. The excellent poster painter Henri de Toulouse-Lautrec is the most famous patient with ca...
Cathepsin K is a cystein protease that displays a proteolytic activity against Type I collagen and i...
Osteogenesis imperfecta (OI) is a genetic disorder principally described by bone brittleness and fra...
Osteoclasts are terminally differentiated cells that attach to bone and secrete proteases to degrade...
Abstract Cathepsin K (CTSK) is a member of the papain-like cysteine protease family. Mutations in th...
The rare osteosclerotic disease, pycnodysostosis, is characterized by decreased osteoclastic bone co...
The rare osteosclerotic disease, pycnodysostosis, is characterized by decreased osteoclastic bone co...
Cysteine proteinases, especially cathepsin K, play an important role in osteoclastic degradation of ...
Cathepsin K (CTSK) is a member of cysteine proteinase family, and is predominantly expressed in oste...
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: ple...
Summary: Osteoclast research has an exciting history and a challenging future. More than 3 decades a...
Background The process of bone resorption by osteoclasts is regulated by Cathepsin K, the lysosomal ...
BACKGROUND: The process of bone resorption by osteoclasts is regulated by Cathepsin K, the lysosomal...
Osteoclastic bone degradation involves the activity of cathepsin K. We found that in addition to thi...
Osteoclastic bone degradation involves the activity of cathepsin K. We found that in addition to thi...
Objective. The excellent poster painter Henri de Toulouse-Lautrec is the most famous patient with ca...
Cathepsin K is a cystein protease that displays a proteolytic activity against Type I collagen and i...
Osteogenesis imperfecta (OI) is a genetic disorder principally described by bone brittleness and fra...
Osteoclasts are terminally differentiated cells that attach to bone and secrete proteases to degrade...
Abstract Cathepsin K (CTSK) is a member of the papain-like cysteine protease family. Mutations in th...
The rare osteosclerotic disease, pycnodysostosis, is characterized by decreased osteoclastic bone co...
The rare osteosclerotic disease, pycnodysostosis, is characterized by decreased osteoclastic bone co...
Cysteine proteinases, especially cathepsin K, play an important role in osteoclastic degradation of ...
Cathepsin K (CTSK) is a member of cysteine proteinase family, and is predominantly expressed in oste...
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: ple...
Summary: Osteoclast research has an exciting history and a challenging future. More than 3 decades a...
Background The process of bone resorption by osteoclasts is regulated by Cathepsin K, the lysosomal ...
BACKGROUND: The process of bone resorption by osteoclasts is regulated by Cathepsin K, the lysosomal...