The Placental Innate Immune System Is Altered in Early-Onset Preeclampsia, but Not in Late-Onset Preeclampsia
- Broekhuizen, Michelle
- Hitzerd, Emilie
- van den Bosch, Thierry P.P.
- Dumas, Jasper
- Verdijk, Robert M.
- van Rijn, Bas B.
- Danser, A. H.Jan
- van Eijck, Casper H.J.
- Reiss, Irwin K.M.
- Mustafa, Dana A.M.
DOIAbstract
Preeclampsia is a severe placenta-related pregnancy disorder that is generally divided into two subtypes named early-onset preeclampsia (onset <34 weeks of gestation), and late-onset preeclampsia (onset ≥34 weeks of gestation), with distinct pathophysiological origins. Both forms of preeclampsia have been associated with maternal systemic inflammation. However, alterations in the placental immune system have been less well characterized. Here, we studied immunological alterations in early- and late-onset preeclampsia placentas using a targeted expression profile approach. RNA was extracted from snap-frozen placenta samples (healthy n=13, early-onset preeclampsia n=13, and late-onset preeclampsia n=6). The expression of 730 immune-related ge...
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