The Etiology of Childhood Pneumonia in Bangladesh: Findings From the Pneumonia Etiology Research for Child Health (PERCH) Study
- Brooks, W. Abdullah
- Zaman, Khalequ
- Goswami, Doli
- Prosperi, Christine
- Endtz, Hubert P.
- Hossain, Lokman
- Rahman, Mustafizur
- Ahmed, Dilruba
- Rahman, Mohammed Ziaur
- Banu, Sayera
- Shikder, Arif Uddin
- Jahan, Yasmin
- Nahar, Kamrun
- Chisti, Mohammod Jobayer
- Yunus, Mohammed
- Khan, Muhammad Alfazal
- Matin, Fariha Bushra
- Mazumder, Razib
- Shahriar Bin Elahi, Mohammad
- Saifullah, Muhammad
- Alam, Muntasir
- Bin Shahid, Abu Sadat Mohammad Sayeem
- Haque, Fahim
- Sultana, Sabiha
- Higdon, Melissa M.
- Haddix, Meredith
- Feikin, Daniel R.
- Murdoch, David R.
- Hammitt, Laura L.
- O'Brien, Katherine L.
- Deloria Knoll, Maria
DOIAbstract
BACKGROUND: Pneumonia remains the leading infectious cause of death among children <5 years, but its cause in most children is unknown. We estimated etiology for each child in 2 Bangladesh sites that represent rural and urban South Asian settings with moderate child mortality. METHODS: As part of the Pneumonia Etiology Research for Child Health study, we enrolled children 1-59 months of age with World Health Organization-defined severe and very severe pneumonia, plus age-frequency-matched controls, in Matlab and Dhaka, Bangladesh. We applied microbiologic methods to nasopharyngeal/oropharyngeal swabs, blood, induced sputum, gastric and lung aspirates. Etiology was estimated using Bayesian methods that integrated case and control data and ac...
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