Effect of age and baseline ASPECTS on outcomes in large-vessel occlusion stroke: results from the HERMES collaboration
- Ospel, Johanna Maria
- Kappelhof, Manon
- Kashani, Nima
- Menon, Bijoy K.
- Campbell, Bruce C. V.
- San Roman, Luis
- Demchuk, Andrew M.
- Dippel, Diederik W. J.
- Saver, Jeffrey L.
- Jovin, Tudor G.
- Mitchell, Peter
- Bracard, Serge
- Muir, Keith
- White, Phil
- Guillemin, Francis
- Majoie, Charles B. L. M.
- Hill, Michael D.
- Brown, Scott
- Goyal, Mayank
DOIAbstract
Background Patient age and baseline Alberta Stroke Program Early CT score (ASPECTS) are both independent predictors of outcome in acute ischemic stroke patients treated with endovascular therapy (EVT). We assessed the combined effect of age and ASEPCTS on clinical outcome in acute ischemic stroke patients with LVO with and without EVT, and EVT treatment effect in different age/ASPECTS subgroups. Methods The HERMES collaboration pooled data of seven randomized controlled trials that tested the efficacy of EVT. Adjusted logistic regression was performed to test for multiplicative interaction of age and ASPECTS with the primary outcome (ordinal mRS) and secondary outcomes (mRS 0-2/0-1/0-3) in the EVT and control arms. Patients were then strati...
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