Dynamic Contrast-enhanced and Diffusion-weighted Magnetic Resonance Imaging for Response Evaluation After Single-Dose Ablative Neoadjuvant Partial Breast Irradiation
- Vasmel, J.E.
- Groot Koerkamp, M.L.
- Mandija, S.
- Veldhuis, W.B.
- Moman, M.R.
- Froeling, M.
- Velden, B.H.M. van der
- Charaghvandi, R.
- Vreuls, C.P.H.
- Diest, P.J. van
- Leeuwen, A.M.G. van
- Gorp, J. van
- Philippens, M.E.
- Asselen, B. van
- Lagendijk, J.J.
- Verkooijen, H.M.
- Bongard, H. van den
- Houweling, A.C.
DOIAbstract
PURPOSE: We aimed to evaluate changes in dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) magnetic resonance imaging (MRI) scans acquired before and after single-dose ablative neoadjuvant partial breast irradiation (NA-PBI), and explore the relation between semiquantitative MRI parameters and radiologic and pathologic responses. METHODS AND MATERIALS: We analyzed 3.0T DCE and DW-MRI of 36 patients with low-risk breast cancer who were treated with single-dose NA-PBI, followed by breast-conserving surgery 6 or 8 months later. MRI was acquired before NA-PBI and 1 week, 2, 4, and 6 months after NA-PBI. Breast radiologists assessed the radiologic response and breast pathologists scored the pathologic response after surgery. Patients w...
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